San Damiano is less than a three hour drive southeast of Saint Louis, Missouri and an hour north of Paducah, Kentucky.

Specifically, we are located 20 miles south of Harrisburg, IL or 10 miles east of Golconda, IL and 2 miles south of the intersection of IL routes 146 & 34. Large highway signs have been erected on at this junction. An all weather road leads to the Shrine entrance where you will find a large entrance monument. 

While San Damiano Retreat has a rural route Golconda, IL mailing address, for GPS devices the closest town  to our actual location is San Damiano.